Double C-H Activation: The Palladium-Catalyzed Direct C-Arylation of Xanthines with Arenes

Publication Type
Journal contribution (peer reviewed)
Authors
Malakar, C. C.; Schmidt, D.; Conrad, J.; Beifuss, U.
Year of publication
2011
Published in
Org. Lett.
Band/Volume
13/6
DOI
10.1021/ol200065s
Page (from - to)
1378-1381
Abstract

The novel Pd-catalyzed C(sp2)-H/C(sp2)-H cross-coupling of unactivated xanthines with unactivated arenes utilizing a combination of Ag(I) and O2 as oxidants exclusively yields C-8 arylated xanthines in a single synthetic operation.

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