Double C-H Activation: The Palladium-Catalyzed Direct C-Arylation of Xanthines with Arenes
- Publikations-Art
- Zeitschriftenbeitrag (peer-reviewed)
- Autoren
- Malakar, C. C.; Schmidt, D.; Conrad, J.; Beifuss, U.
- Erscheinungsjahr
- 2011
- Veröffentlicht in
- Org. Lett.
- Band/Volume
- 13/6
- DOI
- 10.1021/ol200065s
- Seite (von - bis)
- 1378-1381
The novel Pd-catalyzed C(sp2)-H/C(sp2)-H cross-coupling of unactivated xanthines with unactivated arenes utilizing a combination of Ag(I) and O2 as oxidants exclusively yields C-8 arylated xanthines in a single synthetic operation.