Repression mechanisms of the Notch-signalling pathway in Drosophila

Beteiligte Personen

• Manuela Ketelhut
• Dr. rer. nat. Dieter Maier
• apl. Prof. Dr. rer. nat. Anja Christina Nagel
• Prof. Dr. rer. nat. Anette Preiss

• Prof. Dr. R. Kovall (Cincinnati, USA), Prof. Dr. F. Oswald (Uni Ulm), Dr. H. Praxenthaler (Heidelberg) M.Sc. B. Gessler, geb. Brockmann (Inst. 460h)

Beteiligte Einrichtungen

• Fg. Molekulare Genetik

• University of Cincinnati (USA), Universität Ulm

Förderer

• Deutsche Forschungsgemeinschaft

Publikationen im Rahmen des Projekts

• Complex genetic interactions of novel Suppressor of Hairless alleles deficient in co-repressor binding
  2018: Preiss A., Nagel A.C., Praxenthaler H., Maier D.
  
• Analysis of the interaction between human RITA and Drosophila Suppressor of Hairless
  2014: Brockmann, B., Mastel, H., Oswald, F., Maier, D.
  
• Mutation of potential MAPK phosphorylation sites in the Notch antagonist Hairless
  2014: Nagel, A. C., Preiss, A.
  
• Generation of new Hairless alleles by genomic engineering at the Hairless locus in Drosophila melanogaster
  2015: Praxenthaler H., Smylla T.K., Nagel, A.C., Preiss, A., Maier D.
  
• In vivo analysis of internal ribosome entry at the Hairless locus by genome engineering in Drosophila
  2016: Smylla T.K., Preiss A., Maier D.
  
• Structure and function of the Su(H)-Hairless repressor complex, the major antagonist of Notch signaling in Drosophila melanogaster.
  2016: Yuan Z., Praxenthaler H., Tabaja N., Torella R., Preiss A., Maier D., Kovall RA.
  
• Conservation of the Notch antagonist Hairless in Arthropods: functional analysis of the crustacean Daphnia pulex Hairless gene
  2017: Zehender A., Bayer, M., Bauer M. , Zeis B., Preiss A., Maier D.
  
• Hairless-binding deficient Suppressor of Hairless alleles reveal Su(H) protein levels are dependent on complex formation with Hairless
  2017: Praxenthaler H., Nagel A.C., Schulz A., Zimmermann M., Meier M., Schmid H., Preiss A., Maier D.
  
• The Notch repressor complex in Drosophila: In vivo analysis of Hairless mutants using overexpression experiments
  2018: Smylla, T.K., Meier, M., Preiss, A., Maier, D.
  
• Gain of function Notch phenotypes associated with ectopic expression of the Su(H) C-terminal domain illustrate separability of Notch and Hairless-mediated activities.
  2013: Maier, D., Praxenthaler, H., Schulz, A., Preiss, A.